Shoei-Loong Lin, Cheuk-Sing Choy, Wing P Chan and Ting-Kai Leung
The rapid rise of diabetes in Asia and Africa is surpassing that of western countries. Diabetes incurs a significant financial burden on patients and national economies. Consequently, factors such as a miserable life-long treatment of hypoglycemic therapy and the possibility of drug intolerance necessitate a search for non-pharmacological alternatives to reduce the requirement of anti-diabetic drugs. Photoluminescence refers to materials that absorb light energy and then release that energy in the form of light. In this study, Photoluminescence of Bioceramic Materials (PLB) was applied to control hyperglycemia and glycosuria in diabetes from the bench to the clinical bedside examination. The PLB treatments resulted in a tendency to promote glucose diffusion into C2C12 cell line and show a significant decrease in glycosuria in STZ (streptozotocin) induced diabetic rats. The possible mechanisms of the PLB effects on hyperglycemia also correlate with our previous publication and include molecular diffusion, calcium dependent nitric oxide, suppression of oxidative stress and autonomous nervous system regulation. In the future, PLB may have the role of clinical applications on ameliorating hyperglycemia and improving diabetes-related complications.