Yon Mu
Island β- cell dysfunction is a introductory pathophysiological specific of type 2 diabetes mellitus (T2DM). Applicable assessment of islet β- cell function is salutary to further operation of T2DM. guarding islet β- cell function is vital to delay the progress of type 2 diabetes mellitus. therefore, the Pancreatic Island β- cell Expert Panel of the Chinese Diabetes Society and Endocrinology Society of Jiangsu Medical Association organized experts to draft the “ Clinical expert agreement on the assessment and protection of pancreatic islet β- cell function in type 2 diabetes mellitus. ” This agreement suggests that β- cell function can be clinically assessed using blood glucose- predicated styles or styles that combine blood glucose and endogenous insulin or C- peptide situations [1]. Some measures, including weight loss and early and sustained euglycemia control, could effectively cover islet β- cell function, and some lately developed drugs, analogous as Sodium- glucose cotransporter- 2 asset and Glucagon- suchlike peptide- 1 receptor agonists, could meliorate islet β- cell function, independent of glycemic control [2]. The frequency of adult diabetes mellitus in China has increased to11.2, and further than 90 of the cases is type 2 diabetes mellitus (T2DM) (1). Although the precise medium of T2DM development has not been fully clarified, pancreatic islet β- cell dysfunction and insulin resistance are considered two major factors in the pathogenesis of T2DM. Island β- cell function in T2DM cases decreases at an average rate of 2 yearly and extensively declines in cases with a complaint duration of further than 10 times (2). An extensive amount of time is desisted from the full compensation of islet β- cells for glycemia control to complete decompensation, and this period may allow croakers to adopt useful measures to cover islet β- cell function. therefore, rightly assessing islet β- cell function and developing an optimal treatment authority beforehand should contribute to better delaying the progression of T2DM [3].