Gana Manjusha Kondepudi*, Ganga Rao Battu
The aim of the study is to evaluate the antidiabetic activity of aqueous peel extracts of selected fruits viz. Annona squamosa, Cucumis melo, Actinidia deliciosa, Malus pumila. Male wistar albino rats (180-200 g) divided into 12 groups including 1 control group. After induction of diabetes using alloxan, they were treated with selected extracts and polyherbal mixture. At the end of 28th day the animals were sacrificed; blood and pancreatic tissue samples were collected and analysed. All the selected fruit peel extracts and their polyherbal mixture shown significant reduction in the levels of blood glucose and serum lipids such as triglycerides, total cholesterol, LDL, VLDL but increase in HDL, insulin levels. The better action at lowest dose was shown by polyherbal mixture and Malus pumila extract followed by other peel extracts. Histopathological analysis of pancreatic tissue was in concurrence with the biochemical results These findings support that the selected fruit peel extracts and poly herbal mixture showed potent therapeutic effect on diabetes mellitus and can be a potent antidiabetic agent due to their ameliorating effects on damaged pancreas.